Startup ecosystem

Top startups in Boston.

Boston, anchored by MIT and Harvard, is a global leader in biotech and deep tech, with a deep bench of enterprise-software and life-sciences companies spun out of its research institutions.

12 notable startups · 93 funded companies · $7.75B · 30 accelerators · 16 hiring now · Reviewed Sep 2026

Notable startups

A curated list of companies headquartered in Boston, spanning the sectors that define its ecosystem. Each links to the company; where we hold their pitch deck, it's linked too.

HubSpot logo
HubSpot ↗
hubspot.com
Software
Inbound marketing, sales, and CRM platform for growing businesses.
Founded
2006
Stage
Public
Toast logo
Toast ↗
toasttab.com
Software
Restaurant technology platform combining point-of-sale, payments, and operations software.
Founded
2011
Stage
Public
Klaviyo logo
Klaviyo ↗
klaviyo.com
Software
Marketing automation and customer-data platform built for e-commerce brands.
Founded
2012
Stage
Public
Starburst logo
Starburst ↗
starburst.io
Data
Data-analytics platform built on Trino for querying data across many sources at once.
Founded
2017
Stage
Series D
Valuation
~$3.4B
Raised (SEC)
$153M
Open roles
23
DataRobot logo
DataRobot ↗
datarobot.com
AI
Enterprise AI platform for building, deploying, and managing machine-learning models.
Founded
2012
Stage
Late Stage
Circle logo
Circle ↗
circle.com
Crypto
Financial-technology firm and issuer of the USDC stablecoin.
Founded
2013
Stage
Public
Ginkgo Bioworks logo
Ginkgo Bioworks ↗
ginkgobioworks.com
Biotech
Synthetic-biology company engineering microbes and offering cell-programming as a platform.
Founded
2008
Stage
Public
Desktop Metal logo
Desktop Metal ↗
desktopmetal.com
Hardware
Metal and mass-production 3D-printing company for industrial manufacturing.
Founded
2015
Stage
Public
Formlabs logo
Formlabs ↗
formlabs.com
Hardware
Desktop and industrial 3D-printer maker democratizing professional-grade fabrication.
Founded
2011
Stage
Late Stage
Valuation
~$2B
DH
Devoted Health ↗
devoted.com
Health
Technology-driven Medicare Advantage health plan and care provider for seniors.
Founded
2017
Stage
Late Stage
Valuation
~$12B
Flywire logo
Flywire ↗
flywire.com
FinTech
Global payments platform specializing in complex, high-value cross-border transactions.
Founded
2011
Stage
Public
Indigo Ag logo
Indigo Ag ↗
indigoag.com
AgTech
Agtech company using microbiology and data to improve crop yields and sustainability.
Founded
2014
Stage
Late Stage
Valuations are approximate, drawn from the most recent reported figures as of Sep 2026.

Most funded in Boston

By total disclosed across the period, one row per company. Combine filters to narrow — "Recently funded" plus "Hiring now" is who just raised and is actively recruiting.

$669M
Nexamp, Inc. nexamp.com ↗
Energy & Climate · 3 offerings · 38 open roles
$525M
Cengage Learning Holdings II, Inc.
$250M
Starburst Data, Inc.
$227M
Aura Group, Inc. aura.com ↗
Software & Technology · 2 offerings · 5 open roles
$226M
Seaport Therapeutics, Inc.
$159M
$155M
$140M
$135M
Chroma Medicine, Inc.
$133M
$131M
$130M
$129M
Ensoma, Inc.
$126M
Scorpion Therapeutics, Inc.
$121M
Solstice Oncology, Inc.
$112M
PepGen Inc.
$99M
OPEN BLUE SEA FARMS, INC.
$94M
CodaMetrix Inc. codametrix.com ↗
Healthcare · 2 offerings · 1 open roles
$93M
Newleos Therapeutics, Inc.
$85M
$67M
Imbria Pharmaceuticals, Inc.
$66M
$65M
Creatio Inc.
$58M
Accountable Care Transactions, Inc.
$57M
Emulate, Inc.
$55M
Invetx, Inc.
$53M
Bambusa Therapeutics, Inc.
$51M
Ratio Therapeutics, Inc.
$45M
1upHealth, Inc.
$45M
Ankyra Therapeutics, Inc.
$43M
SimSpace Corp
$42M
$42M
Botkeeper Inc.
$41M
Abacus Insights, Inc.
$41M
ACTIV Surgical, Inc.
$40M
$40M
Lookout, Inc.
$38M
Teikametrics, Inc.
$38M
Memento Medicines, Inc.
$38M
Carbon Biosciences, Inc.
$36M
Bicycle Health Inc.
$35M
Coin Metrics Inc.
$32M
Aliada Therapeutics, Inc.
$32M
OcuTerra Therapeutics, Inc.
$31M
Notarize, Inc.
$31M
Appcues, Inc.
$30M
Consensus NLP Inc.
$30M
Appex Group, Inc.
$29M
HYCU Holdings, Inc.
$29M
Centrexion Therapeutics Corp
$28M
Robin Powered, Inc.
$27M
Tidelift, Inc.
$25M
Lonestar Medicines, Inc.
$25M
PERCH ENERGY, INC.
$25M
SYNTIS BIO, INC.
$24M
Amplitude Vascular Systems, Inc.
$23M
MediSix Therapeutics, Inc.
$22M
Biothea Pharma, Inc.
$22M
NormShield Inc.
$22M
Elicio Therapeutics, Inc.
$22M
123 See, Inc.
$22M
CyberSaint, Inc.
$21M
$21M
Paperless Parts, Inc.
$21M
GT Spirits, Inc.
$20M
BetterVet, Inc.
$20M
NFlection Therapeutics, Inc.

Filter definitions — Hiring now: open roles on the company's public job board as of Sep 5, 2026. Hiring remote: that board lists remote or distributed roles. Recently funded: a Form D filed in the trailing twelve months. $100M+/$500M+: cumulative disclosed amount across all offerings. Repeat raisers: more than one offering on file. Up-and-coming: incorporated within the last four years and recently funded — incorporation year is disclosed by roughly half of filers, so this undercounts.