Startup ecosystem

Top startups in San Diego.

55 San Diego companies have disclosed $7.41B in SEC filings, and founders there can apply to 11 accelerator programs.

55 funded companies · $7.41B · 11 accelerators · 3 hiring now · Reviewed Jul 2026

Most funded in San Diego

By total disclosed across the period, one row per company. Combine filters to narrow — "Recently funded" plus "Hiring now" is who just raised and is actively recruiting.

$946M
Shield AI Inc shield.ai ↗
Software & Technology · 3 offerings · 1 open roles
$427M
Drata Inc. drata.com ↗
Software & Technology · 3 offerings · 55 open roles
$413M
$399M
Mango Technologies, Inc.
$206M
Candid Therapeutics, Inc.
$196M
CORTICA INC.
Healthcare · 2 offerings
$168M
RayzeBio, Inc.
$142M
NetraDyne, Inc.
$140M
Shoreline Biosciences, Inc.
$130M
DroneBase, Inc.
$120M
Saral, Inc.
$119M
GENOMATICA INC
$105M
Vignette Bio, Inc.
$101M
Kandji, Inc.
$100M
Boundless Bio, Inc.
$90M
TRC 2004, Inc.
$85M
Aardvark Therapeutics, Inc.
$63M
Aristea Therapeutics, Inc.
$60M
Escient Pharmaceuticals Inc
$58M
Angiocrine Bioscience, Inc.
$55M
ARS Pharmaceuticals, Inc.
$45M
Empirico Inc.
$43M
Zerigo Health, Inc.
$40M
1859, Inc.
$32M
$32M
VST BIO Corp
$30M
Kumquat Biosciences Inc
$29M
Vektor Medical, Inc.
$27M
SkySafe, Inc.
$26M
Molecular Assemblies, Inc.
$23M
DEBUT BIOTECHNOLOGY, INC.
$20M
Replicate Bioscience, Inc.

Filter definitions — Hiring now: open roles on the company's public job board as of Aug 10, 2026. Hiring remote: that board lists remote or distributed roles. Recently funded: a Form D filed in the trailing twelve months. $100M+/$500M+: cumulative disclosed amount across all offerings. Repeat raisers: more than one offering on file. Up-and-coming: incorporated within the last four years and recently funded — incorporation year is disclosed by roughly half of filers, so this undercounts.

Accelerators in San Diego

San Diego founders can apply to 11 accelerator programs in our directory — including Baker & Eastlack Ventures, Carib Ventures, LLC, Connect All, Forward Ventures, Hera Labs, IDK Distribution, Inc.

The best accelerators in San Diego → Accelerators with open applications →