Startup ecosystem

Top startups in South San Francisco.

38 South San Francisco companies have disclosed $4.28B in SEC filings.

38 funded companies · $4.28B · 4 hiring now · Reviewed Jul 2026

Most funded in South San Francisco

By total disclosed across the period, one row per company. Combine filters to narrow — "Recently funded" plus "Hiring now" is who just raised and is actively recruiting.

$265M
Sonoma Biotherapeutics, Inc.
$243M
Freenome Holdings, Inc.
$202M
NewLimit, Inc. newlimit.com ↗
Biotech & Pharma · 2 offerings · 17 open roles
$173M
Venn Biosciences Corp
$169M
ALUMIS INC. alumis.com ↗
Biotech & Pharma · 2 offerings · 17 open roles
$156M
SonoThera, Inc. sonothera.com ↗
Biotech & Pharma · 2 offerings · 4 open roles
$148M
Glydways, Inc. glydways.com ↗
Software & Technology · 2 offerings · 12 open roles
$134M
Electra Therapeutics, Inc.
$88M
Frontier Medicines Corp
$85M
Verge Analytics, Inc.
$73M
Septerna, Inc.
$66M
Circle Pharma, Inc.
$53M
Mahzi Therapeutics Inc.
$50M
Interline Therapeutics, Inc.
$50M
Moonwalk Biosciences, Inc.
$42M
TRex Holdings Inc.
$41M
Terremoto Biosciences, Inc.
$40M
Firefly Bio, Inc.
$40M
Perceive Biotherapeutics, Inc.
$33M
Dualitas Therapeutics, Inc.
$29M
Walking Fish Therapeutics, Inc.
$27M
Spiral Therapeutics Inc
$26M
Burnbot, Inc.

Filter definitions — Hiring now: open roles on the company's public job board as of Aug 10, 2026. Hiring remote: that board lists remote or distributed roles. Recently funded: a Form D filed in the trailing twelve months. $100M+/$500M+: cumulative disclosed amount across all offerings. Repeat raisers: more than one offering on file. Up-and-coming: incorporated within the last four years and recently funded — incorporation year is disclosed by roughly half of filers, so this undercounts.